Rumba Mens Health Blog

UroToday.com - Dr. Kevin McVary (Chicago) presented the AUA lecture. The incidence of ED increases to over 60% by age 60. He showed data that ED increases with increasing severity of LUTS, independent of age. Across all age groups, increasing LUTS correlated with worse ED even after adjusting for other factors such as diabetes mellitus. This suggests a common pathophysiology or causal relationship between ED and LUTS.
In the MTOPS data, sexual function domains were stratified against AUA symptom indices and all sexual function domains correlated with LUTS. Prostate volume also correlated with ED as increasing size and worsening ED were linked. Several theories may explain these findings. Nitros oxide (NO) can be reduced by smoking, diabetes, etc. and result in prostatic hyperplasia that contributes to LUTS. In a canine prostate model, exposure to NO results in increased relaxation of smooth muscle, consistent with the hypothesis. Dr. McVary’s research has shown decreased NO as men age. The enzyme PDE-5 in the prostate and bladder is increased and may contribute to ED. Experimental models of PDE-5 inhibitors result in increased smooth muscle relaxation.
He spoke about using the PDE-5 inhibitor concept to treat LUTS. A placebo run-in phase is important in LUTS trials. Sildenafil was tested in a combined ED/LUTS trial, and LUTS scores improved by over 6 points. Both obstructive and irritative scores improved. He cited Dr. Steif’s vardinafil study that also demonstrated an improvement in LUTS. Despite symptom improvement, Dr. McVary did not find any improvement in urinary flow rate.
comprare il viagra senza ricetta He also spoke about atherosclerosis induced chronic ischemia causing bladder and penile fibrosis and contributing to both voiding and erectile symptoms. Another theory is that increased autonomic activity correlates to ED and LUTS. He presented data in patients to support this correlation. A causal relationship was not demonstrated. Increased sympathetic tone from obesity, physical inactivity and other causes lead to effects on erectile function and LUTS.
Presented by: Kevin McVary, MD, at the European Association of Urology - 23rd Annual EAU Congress - March 26 - 29, 2008 - Milan, Italy
Reported by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS
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Erectile dysfunction (ED) has a dramatic impact on quality of life. Treatments for ED continue to improve, and penile prostheses have one of the highest patient satisfaction rates. In the April 2008 issue of Urologic Nursing, Susanne A. Quallich, Dana A. Ohl and Rodney L. Dunn survey urologic health care practitioners to find the penile prosthesis pump that is easiest to use and teach to patients.
Participants found the Coloplast Titan® One-Touch Release pump design was more user friendly, say the authors. Participants also felt they could quickly and reliably teach patients to use the device. Kaufen generishe cialis soft With faster instruction time and ease of use, Quallich and co-authors say patient satisfaction rates will increase.
If patients can be trained quickly and effectively, say the authors, the trainer’s time is used more efficiently, patient satisfaction goes up, and the patient gains confidence that he can operate the device at home. Quallich and co-authors believe this could represent an overall time and cost savings to urology practices and fewer repeat visits.
"Evaluation of Three Penile Prosthesis Pump Designs in a Blinded Survey of Practitioners"
Susanne A. Quallich, APRN, BC, NP-C, CUNP; Dana A. Ohl, MD; Rodney L. Dunn, MS
Urologic Nursing; April 2008; www.suna.org)
About SUNA (Society of Urologic Nurses and Associates)
The Society of Urologic Nurses and Associates is a national, non-profit professional membership association with over 3,000 members and annual revenues of $1.5 million. SUNA derives its income from membership dues ($60), conference registration fees, exhibits, advertising, grants, and the sale of educational products.
SUNA publishes a professional, peer-reviewed bi-monthly journal (Urologic Nursing Journal) and a bi-monthly newsletter (Uro-Gram). SUNA establishes the scope and standards of urologic nursing practice and the scope and standards of advanced urologic nursing practice. SUNA provides scholarships, grants and awards to deserving nurses and other health care professionals. SUNA supports and promotes the certification of urologic nurses and associates by providing educational preparation for the examinations offered which lead to certification in three areas. SUNA provides a variety of opportunities for participation including local chapters, task forces and Special Interest Groups (SIGS) in five major subspecialty areas.
www.suna.org
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Smoking cigarettes causes cancer and increases the risk of cardiovascular and other diseases, but there’s even more bad news for men who smoke. They have an increased risk of experiencing erectile dysfunction, and the more cigarettes smoked, the greater the risk, according to a study by Tulane University researchers published in the American Journal of Epidemiology.
Although erectile dysfunction, the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance, is not a life-threatening condition, it compromises well-being and quality of life. The study results suggest that smoking prevention is an important approach for reducing the risk of erectile dysfunction.
A team of researchers led by Jiang He, professor and chair of epidemiology at the Tulane University School of Public Health and Tropical Medicine, examined the association between cigarette smoking and erectile dysfunction in a 2000-2001 study in China involving 7,684 men. The researchers used questionnaires to assess the status of cigarette smoking and erectile dysfunction.
"The association between cigarette smoking and ED was found in earlier studies," says He. "However, most of those studies were conducted in patients with hypertension, diabetes and cardiovascular disease. What distinguishes this study is that it is the first to find this association among healthy men."
comprare il viagra senza ricetta Jiang He, professor and chair of epidemiology, leads the team of researchers who examined the association between cigarette smoking and erectile dysfunction in men.
Those surveyed by the team were men between the ages of 35 to 74 who did not have vascular disease. The researchers also found that there was a significant statistical link between the number of cigarettes that the men smoked and the likelihood they would experience erectile dysfunction. Overall, an estimated 22.7 percent of erectile dysfunction cases among Chinese men might be attributable to cigarette smoking, according to the study.
"This study was conducted in China, but of course these results also apply to the U.S. population," says He.
More than 18 million American men — nearly one in five — experience erectile dysfunction, according to a study this year from the Bloomberg School of Public Health at Johns Hopkins University.
"There have been studies done in this country that show the same association between cigarette smoking and ED, but those were conducted in patients with diabetes, hypertension or cardiovascular disease. Our study shows that even in healthy men the association is very strong," He concludes.
Raising further caution flags about the dangers of starting to smoke cigarettes, the researchers found that even when cigarette smokers quit, their risk of developing erectile dysfunction did not decrease. The risk is statistically about the same for former cigarette smokers as for current cigarette smokers.
"This study really has a strong message for young men," He says. "It may get their attention if they know that smoking is associated with ED even in the healthy population. So the message is: Don’t start."
Tulane University
215 Gibson Hall
New Orleans, LA 70118-5698
United States

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Men’s Health News
Genetic changes during the initiation and progression of prostate cancer have eluded scientists to date. Now for the first time researchers have identified a specific gene expression profile of prostate cancer stem cells, with important implications for future treatments.
The findings, published in BioMed Central’s open access journal Genome Biology, revealed 581 genes that are differentially expressed in certain prostate cancer cells, highlighting several pathways important in the cancer stem-cells biology, and offering targets for new chemopreventative and chemotherapeutic approaches.
The cells in the study represent less than 0.1% of prostate cancer tumors, and have properties that mark them out as cancer stem cells. The cells renew themselves, are highly invasive, and have a longer lifetime than normal stem cells. They also feature a primitive epithelial phenotype and can differentiate to recapitulate phenotypes seen in prostate tumors. The cells are found in all stages and types of prostate cancer.
Expression profiling of prostate cancers typically uses tumor cell mass samples to identify individual genes. In this study, researchers harnessed advances in microarray and target labelling technologies to produce a functionally annotated expression profile of these prostate cancer stem cells.
The team, from the YCR Cancer Research Unit at the University of York and Pro-cure Therapeutics Ltd, created a malignant stem cell signature by combining genes significantly overexpressed in stem cells with those significantly overexpressed in malignant stem cells. Quantitative RT-PCR, flow cytometry and immunocytochemistry were used to validate the gene expression changes.
Genes associated with inflammation were prominent in the cancer stem cell expression profile. Potential therapeutic target NF?is known to promote cell survival. The researchers showed that an NF?inhibitor triggered programmed cell death in cancer stem cells, but spared normal stem cells. This provides a potential therapeutic target for this rare group of cells, which are unlikely to be affected by current chemotherapy regimens.
"Generic lasix pills no prescription For the first time we are looking at the subpopulation of cancer cells which actually initiate new tumors" explains Anne Collins, who coordinated the study. "The genetic profiling we have carried out should stimulate new lines of research directed towards stem cell treatments for cancer"

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Men’s Health News
Men who come to the hospital with pneumonia generally are sicker than women and have a higher risk of dying over the next year, despite aggressive medical care, according to a study being presented Tuesday, May 20, at the 104th International Conference of the American Thoracic Society. Scientific sessions are scheduled May 16 to 21 in Toronto.
"It is well known that women live longer than men. We have always assumed that these differences occur because men engage in riskier behaviors and have a greater burden of chronic diseases," said Sachin Yende, M.D., study co-author and assistant professor in the Department of Critical Care Medicine, University of Pittsburgh School of Medicine. "Our study showed that men were more likely to die up to a year after pneumonia, despite adjusting for health behaviors and chronic conditions. Further, our findings indicate this may be linked to differences in immune response."
The University of Pittsburgh researchers evaluated data from 1,136 men and 1,047 women with symptoms of pneumonia who were treated at 28 hospital emergency departments in the United States.
On average, men arrived at the emergency departments with poorer vital signs, were more likely to be smokers and had a greater variety of complicating health conditions. Kaufen generishe cialis soft After hospitalization, men received timely antibiotic treatments more often than women and were twice as likely to be admitted immediately to intensive-care units.
"The gender disparity on aggressiveness of hospital care is appropriate, given that men tended to be significantly sicker than women," said Michael Reade, D.Phil., first author, former fellow in Pitt’s Department of Critical Care Medicine, and assistant professor at the University of Melbourne, Australia. Investigators adjusted results for age, race, tobacco use, other demographic characteristics, chronic health conditions, health behaviors and levels of treatment. "Even so, men had a 30 percent higher risk of death, and the social factors we examined were not sufficient to explain the differences we observed."
Using the patient data, Drs. Reade, Yende and their colleagues next examined a series of molecules important to the body’s immune response to infection, finding significant differences between men and women in levels of tumor necrosis factor, interleukin-6, interleukin-10, antithrombin III, Factor IX, plasminogen activator inhibitor-1 and D-dimer. By comparison between the genders, some concentrations were lower, while others were higher.
"No one had shown this before," said Dr. Yende. "So these differences in immune response could explain at least some of the differences in survival."
Gender differences in immune response to infection are an area of intensive research, with investigations into the role of X chromosomes, which encode genes for several important immune system mediators. "Some investigators have suggested that the immune response may differ because women have two copies of the X chromosome," said Dr. Yende. "Sex hormones are another area of inquiry. It is tempting to speculate that in the future, medical treatment of pneumonia may be different for men and women."

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